Dr. Syed Sikander Azam

Designation: Assistant Professor
Email Address:  This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
Office Phone:  +92-051 9064-4130
Office: National Centre for Bio Informatics, Quaid-i-Azam University, Islamabad 
PhD  Computational Chemistry at Theoretical Chemistry Division, University of Innsbruck, Austria
Other Links (National Center for Proteomics | HEC)  

 

Ph.D: Computational Chemistry at Theoretical Chemistry Division, University of Innsbruck, Austria.
M.Sc: Department of Biotechnology, University of Karachi, Pakistan.
B.Sc: DJ Science College, University of Karachi in Chemistry, Microbiology, Biochemistry

Dr. Sikander has 46 publications in internationally well known journals and two publications of national journals on his credit. He has accomplished his Ph.D from the University of Innsbruck, Austria, in the field of Theoretical and Computational Chemistry. Current research interests lied in the field of Computational Biochemistry.In particular, Molecular Docking and Molecular Dynamic (MD) Simulations of proteins for understanding structural and dynamical aspects of the biological system. The application of Molecular Mechanic ( MM) , and Hybrid Quantum Mechanical / Molecular Mechanical (QM/MM) Molecular Dynamic (MD), and Quantum Mechanical Charge Field (QMCF) Molecular Dynamic Simulations for the evaluation of structural and dynamical properties of biologically and industrially important ions in aqueous solution are another dimensions of his interests. He is currently establishing a computational facility lab at the National Centre for Bioinformatics which helps to maintain the synergistic relationship with the experimental research work carried out on various proteins at the resource lab of the institute. 

1.

 

Iqbal, S., Shamim, A., Azam, S.S., & Abdul Wadood., (2016). Identification of potent inhibitors for chromodomain-helicase- DNA-binding protein 1-like through moleculardocking studies. Medicinal Chemistry Research, pp.1-16.


2.

 

Abro, A., & Azam, S. S.(2016). Binding free energy based analysis of arsenic (+ 3 oxidation state) methyltransferase with S-adenosylmethionine. Journal of Molecular Liquids220, 375-382.


3.

 

Abbasi, S., Raza, S., Azam, S. S., Liedl, K. R., & Fuchs, J. E. (2016). Interaction mechanisms of a melatonergic inhibitor in the melatonin synthesis pathway. Journal of Molecular Liquids


4.

 

Zawawi N.K.N.A, Muhammad Taha, Ahmat N, Wadood A, Ismail N.H, Rahim F, Azam, S. S., Abdullah N, (2016). Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies. Bioorganic Chemistry. 64, 29–36. DOI:10.1016/j.bioorg.2015.11.006.

 

5.

 

Cerón-Carrasco, J.P., Coronado-Parra, T., Imbernón-Tudela, B., Banegas-Luna, A.J., Ghasemi, F., Vegara-Meseguer, J.M., Luque, I., Azam, S.S., Trædal-Henden, S. and Pérez-Sánchez, H., (2016). Application of Computational Drug Discovery Techniques for Designing New Drugs against Zika Virus. Drug Designing: Open Access2016.

 

6.

 

Andleeb,S., Imtiaz-ud-Din., Rauf, M.K., Azam, S.S., Badshah, A., Sadaf, H., Raheel, A., Nawaz Tahir, M., & Raza S., (2016). A one-pot multicomponent facile synthesis of dihydropyrimidin-2(1H)-thione derivatives using triphenylgermane as a catalyst and its binding pattern validation. RSC Advances DOI: 10.1039/C6RA19162B.


7.

 

Uddin, R., Azam, S.S., Wadood, A., Khan, W., Farooq, U. and Khan, A., (2016). Computational identification of potential drug targets against Mycobacterium leprae. Medicinal Chemistry Research, pp.1-9. es New Roman",vitro Anti‐Leishmanial Potential of Peptide Drug Hirudin. Chemical Biology & Drug Design.  10.1002/ardp.201500312. 

 

8.

 

Khan, H., Nadhman, A., Azam, S. S., Anees, M., Khan, I., Ullah, I., & Yasinzai, M. (2016). In‐vitro Anti‐Leishmanial Potential of Peptide Drug Hirudin. Chemical Biology & Drug DesignRoman", 10.1002/ardp.201500312.

 

9.

 

Rauf, M. K., Shaheen, U., Asghar, F., Badshah, A., Nadhman, A., Azam, S. S.,  & Yasinzai, M. (2016). Antileishmanial, DNA Interaction, and Docking Studies of Some Ferrocene‐Based Heteroleptic Pentavalent Antimonials. Archiv der Pharmazie. DOI: 10.1002/ardp.201500312.

 

10

 

A., Wadood, M., Ghufran, S.F, Hassan, H., Khan, S.S,Azam & U., Rashid (2016). In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria. Pharmaceutical Biology. Pp. 1-14.: 10.1111/dgd.12239

 

11. 

 

S., Ali,B., Amina,S., Anwar,R., Minhas,N., Parveen,U., Nawaz, S.S, Azam & Abbasi A.A., (2016), Genomic features of human limb specific enhancers. Genomics. on of novel transcriptional enhancers involved in regulating human GLI3 expression during early development. Development, growth & differentiation, 57(8), 570-580. DOI: 10.1111/dgd.12239

 

12. 

 

Uddin R, Saeed K,  Khan W,  Azam S.S, & Wadood A., (2015). Metabolic pathway analysis approach: identification of novel therapeutic target against methicillin resistant Staphylococcus aureusGene, 556(2), 213-226.


13. 

 

Wajid Abbasi, S., & Azam, S. S.,(2015). Structural Characterization of Alpha-methylacyl-CoA Racemase: Comparative Structural Modeling, Molecular Docking and Dynamic Simulations Studies. Current cancer drug targets, 15(9), 822-835.


14. 

 

Anwar, S., Minhas, R., Ali, S., Azam, S. S & Abbasi, A. A. (2015). Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development. Development, growth & differentiation, 57(8), 570-580. DOI: 10.1111/dgd.12239


15.

 

Shamim, A., Abbasi, S. W., & Azam, S. S. (2015). Structural and dynamical aspects of Streptococcusgordonii FabH through molecular docking and MD simulations. Journal of Molecular Graphics and Modelling. DOI: 10.1016/j.jmgm.2015.05.013

 

16.

 

Hammad M. A., Azam S. S. (2015). Structural dynamics and inhibitors searching for Wnt-4 protein using comparative computational studies. Drug, Design, Development and therapy. 5(9), 2449-2461. DOI: 10.2147/DDDT.S79784 

 

17.

 

Azam, S. S.*, Abro A., Raza S. (2014). Binding Pattern Analysis and Structural Insight into the Inhibition Mechanism of Sterol 24-C Methyltransferase by Docking and Molecular Dynamics Approach. Journal of Bio molecular Structure & Dynamics.DOI:10.1080/07391102.2014.1002423

 

18.

 

Azam, S. S.*, & Shamim, A. (2014). An Insight into the Exploration of Druggable Genome of Streptococcus gordoniifor the Identification of novel Therapeutic Candidates. Genomics. [In press]. *Corresponding Author

 

19. 

 

Uddin, R., Saeed, K., Khan, W., Azam, S. S., & Wadood, A. (2014). Metabolic pathway analysis approach: Identification of novel therapeutic target against methicillin resistant Staphylococcus aureus. Gene.

 

20.

 

Azam, S. S.*, & Hammad, M. A. (2014). Role of thumb index fold in Wnt-4 protein and its dynamics through a molecular dynamics simulation study. Journal of Molecular Liquids. DOI: 10.1016/j.molliq.2014.07.007. *Corresponding Author

 

21.

 

Gul R., Rauf M. K., Badshah A., Azam S. S., Tahir M. N., Khan A. (2014) Ferrocene-based guanidine derivatives: In vitro antimicrobial, DNA binding and docking supported urease inhibition studies. European Journal of Medicinal Chemistry. 85, 438-449.

 

22.

 

Azam, S. S.*, Sarfaraz, S., & Abro, A. (2014). Comparative modeling and virtual screening for the identification of novel inhibitors for myo-inositol-1-phosphate synthase. Molecular biology reports, 23(9):4108-4137. *Corresponding Author

 

23.

 

Azam S. S.*, Abbasi S. W., Tahir S. (2014) Investigation of novel chemical inhibitors of human Lysosomal acid lipase: Virtual Screening and Molecular Docking Studies. Combinatorial Chemistry & High Throughput Screening. 17(5):473-482. *Corresponding Author

 

24.

 

Azam S. S.*, Abbasi S. W., Akhtar A. S., Laka M. (2014) Comparative modeling and molecular docking studies of D-Alanine:D-alanine ligase: a target of antibacterial drugs. Medicinal Chemistry Research. 23(9):4108-4137. *Corresponding Author

 

25.

 

Azam S. S.*, Abro A., Raza S., Saroosh A. (2014) Structure and Dynamics studies of Sterol-24-C-Methyltransferase with mechanism based inactivators for the disruption of Ergosterol biosynthesis. Molecular Biology Reports. 41(7):4279-4293. *Corresponding Author


26.

 

Azam S. S.*, Abro A., Tanvir F., Pervaiz N. (2014) Identification of Unique Binding Site and Molecular docking Studies for Structurally Diverse Bcl-xL Inhibitors. Medicinal Chemistry Research. 23(8):3765-3783. *Corresponding Author

 

27.

 

Azam S.S.* and Raza S. (2014) Structure modeling and hybrid virtual screening study of alzheimer's associated protease Kallikrein8 for the identification of novel inhibitors. Medicinal Chemistry Research. 23(7):3516-3527. *Corresponding Author


28.

 

Azam, S.S.*, Abbasi, S.W. and Batool M. (2014) Structure modeling and docking study of HCV NS5B-3A RNA polymerase for the identification of potent inhibitors. Medicinal Chemistry Research. 23(2):618-627. *Corresponding Author


29.

 

Azam, S.S.* and Abbasi, S.W. (2013) Molecular docking studies for the identification of novel melatoninergic inhibitors for acetylserotonin-O-methyltransferase using different docking routines. Theoretical Biology and Medical Modelling. 10:63  doi:10.1186/1742-4682-10-63 *Corresponding Author

 

30. 

 

Azam, S. S.*, Abbasi, S.W., Batool M. (2013) Structure modeling and docking study of HCV NS5B-3A RNA polymerase for the identification of potent inhibitors. Medicinal Chemistry Research. 23(2): 618-627. DOI:10.1007/s00044-013-0666-5

 

31.

 

Azam, S.S.*and Muhammad Jan Akhunzada (2013) Structure and dynamic studies of lunatic, manic and radical fringe. Journal of Molecular Liquids.  188, 186-195 *Corresponding Author

 

32.

 

Azam, S.S.*, Saroosh, A., Zaman, N., & Raza, S. (2013) Role of N-Acetylserotonin O-methyltransferase in Bipolar Disorders and its dynamics. J. Mol. Liq. 182, 25-31 *Corresponding Author


33.

 

Yasir, M., Khan, H., Azam, S.S., Telke, A., Kim, S. W., & Chung, Y. R. (2013). Cloning and functional characterization of endo-β,4-glucanase gene from metagenomic library of vermicompost. Journal of Microbiology 51(3):329-35. doi: 10.1007/s12275-013-2697-5

 

34.

 

Azam S.S*. 2012. Computational Studies of Complexes and Biomolecules. Pages 292: LAP LAMBERT Academic Publishing. *Corresponding Author
 

35.

 

Azam S.S*, Reaz Uddin, Abdul Wadood, Structure and dynamics of alpha-glucosidase through molecular dynamics simulation studies, Journal of Molecular Liquids, Volume 174, October 2012, Pages 58-62, ISSN 0167-7322, 10.1016/j.molliq.2012.07.003*Corresponding Author
 

36.

 

Azam S.S, Shamshad Zarina (2012). Distribution of biological databases over lowbandwidth networks. 


37.

  

Ammara Saleem, Azam S.S & Shamshad Zarina (2012). Docking and molecular dynamics simulation studies on glycation-induced conformational changes of human paraoxonase 1. ISSN 0175-7571, Volume 41, Number 2.
 

38.

 

Azam S.S*. Uddin, R. Shah, A.A. "Molecular docking studies of potent inhibitors of typosinase and α - glucosidase*Corresponding Author
 

39.

 

Azam S.S. "Classical and QM/MM MD simulations of sodium(I) and potassium(I) ions in aqueous solution". J. Mol. Liq. 153; (2-3) 95-100.
 

40.

 

Lim L.H.V, Bhattacharjee A., Azam S.S., Hofer T.S., Randolf B.R., Rode B.M. "Structural and Dynamical Aspects of the Unsymmetric Hydration of Sb(III): An ab initio Quantum Mechanical Charge Field Molecular Dynamics Simulation". Inorg. Chem. 49; (5) 2132
 

41.

 

Azam S.S., Lim L.H.V., Hofer T.S., Randolf B.R., Rode B.M. "Hydrated germanium (II): Irregular structural and dynamical properties revealed by a quantum mechanical charge field molecular dynamics study".J. Comput. Chem. 31; (2) 278-285.
 

42.

 

Azam S.S.,Hofer T.S., Bhattacharjee A., Lim L.H.V., Pribil A.B., Randolf B.R., Rode B.M. "Beryllium(II): The Strongest Structure-Forming Ion in Water? A QMCF MD Simulation Study".J. Phys. Chem. B, 113; (27) 9289-9295.
 

43.

 

Azam S.S., Hofer T.S., Randolf B.R., Rode B.M. "Hydration of Sodium(I) and Potassium(I) Revisited: A Comparative QM/MM and QMCF MD Simulation Study of Weakly Hydrated Ions." J. Phys. Chem. A,113; (9) 1827-1834.
 

44.

 

Azam S.S., Hofer T.S., Randolf B.R., Rode B.M. "Germanium (II) in water: an Unusual HydrationStructure Results of a QMCF MD Simulation." Chem. Phys. Lett. 470; 85-89.


45.

 

Clinicomorphological Features of Cholecystitis and Cholelithiasis Sikander Azam, Mashood-ul-Haque-Qazi, Zuhaib Ismail, Mohammad Ammad Saeed, Mohammad Farooq Anis and Syed Zubair Ahmed Zaidi Journal of Pakistan Medical Association 2005, Vol. 55, No. 12 (Suppl. 2)

 

46.

 

Clinico-pathological Features and Incidence of Gallbladder Cancer in Karachi locally published in Journal of Pakistan Medical Association 2005, Vol. 55, No. 12 (Suppl. 2).

 

 

 

 

ENROLLED STUDENTS

MPhil

PhD

1. 

Ghulam Abbass

Saad Raza

2. 

Mawra Irshad

Sajjad Ahmad

3. 

Shehneela Baseer

Amen Shamim

4. 

Yelda Asad

Saneela Anwar

5. 

Nosheen Ehsan

 

6. 

Zuneera Khalid

 

7. 

Qurat Ul Ain

 

PRODUCED STUDENTS

MPhil

PhD

1. 

Farhan ul haq

Sumra Wajid Abbasi 

2. 

Gul Sanober

Asma Abro 

3. 

Sundus Iqbal

4. 

Noor ul Ain Sajid Mughal

5. 

Fouzia Shaheen

6. 

Iqra Ahmed

7. 

Sanam Javed Khan

8. 

Nimra Sabir

9. 

Seemab Khurshid

10. 

Hira Jabeen

11. 

Anum Khalid

12. 

Iqra Shehzadi

13. 

Saba Hassan

14. 

Amina Saleem Akhtar

15. 

Farya Tanvir

16. 

Mah-Laka

17. 

Syeda Marzia Zehra Rizvi

18. 

Nousheen Parvaiz

19. 

Amen Shamim

20. 

Nida Khalid

21. 

Maria Batool

22. 

Sara Sarfraz

23. 

Shifa Tahir

24. 

Mirza Ahmed Hammad ul Mubeen Muhammad

25. 

Muhammad Jan Akhunzada

26. 

Saad Raza

27. 

Naila Zaman

28. 

Ayman Saroosh