Dr. Sajid Rashid (Chairperson)

Dr. Sajid Rashid

Designation: Professor (Chairperson)
National Centre for Bioinformatics, Quaid-i-Azam University, Islamabad
Email Address: sajid@qau.edu.pk
Office Phone: +92-051-9064-4107
Postdoc: International Institute of Molecular and Cell Biology, Poland
Ph.D: George-August University, Germany
Other links: Functional Informatics Lab | Research Gate | HEC | Google Scholar

Research Interest's:-

Protein-protein interaction studies

Our main focus is to identify novel protein complexes and pathways involved in cancerogenesis both by wet lab and dry lab techniques. In parallel to protein interaction studies, we also characterize novel drug targets computationally.

Experimental approaches include, cloning, BN-PAGE, coimmunoprecipitation assay, GST-pull down, Ni-NTA method, immunostaining, whole mount in situ hybridization, chromatin immunoprecipitation assays and 2D-gel assays.

Rashid et al., 2009 (J. of Biological Chemistry)

Publications:-

  1. Gul, M., Fakhar, M., & Najumuddin, S. R. (2019). Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors. PLOS ONE, 14(11).
  2. Malik, S. S., Zia, A., Mubarik, S., Masood, N., Rashid, S., Sherrard, A., … & Khadim, M. T. (2019). Correlation of MLH1 polymorphisms, survival statistics, in silico assessment and gene downregulation with clinical outcomes among breast cancer cases. Molecular Biology Reports.
  3. Sameera, S. Y., & Rashid, S. (2019). Structural studies of Staphylococcus aureus Sortase inhibition via Conus venom peptides. Archives of Biochemistry and Biophysics.
  4. Shafique, S., & Rashid, S. (2019). Structural basis of βTrCP1-associated GLI3 processing. Scientific Reports, 9(1), 6865.
  5. Bibi, N., Niaz, H., Hupp, T., Kamal, M. A., & Rashid, S. (2019). Screening and Identification of PLK1-Polo Box Binding Peptides by High-Throughput Sequencing of Phage-Selected Libraries. Protein and Peptide Letters, 26(8), 620-633.
  6. Bibi, N., Rashid, S., Nicholson, J., Malloy, M., O’Neill, R., Blake, D., & Hupp, T. (2019). An Integrative “Omics” Approach for Identification of Bona Fides PLK1 Associated Biomarker in Esophageal Adenocarcinoma. Current Cancer Drug Targets, 19(9), 742-755.
  7. Shafique, S., & Rashid, S. (2019). Structural basis for renal cancer by the dynamics of pVHL-dependent JADE1 stabilization and β-catenin regulation. Progress in Biophysics and Molecular Biology, 145, 65-77.
  8. Fakhar, M., Gul, M., & Rashid, S. (2018). Antagonistic role of Klotho-derived peptides dynamics in pancreatic cancer treatment through obstructing WNT-1 and Frizzled binding. Biophysical Chemistry, 240, 107-117.
  9. Najumuddin, Fakhar, M., Gul, M., & Rashid, S. (2018). Interactive structural analysis of βTrCP1 and PER2 phosphoswitch binding through dynamics simulation assay. Archives of Biochemistry and Biophysics.
  10. Ali, W., Shafique, S., & Rashid, S. (2018). Structural characterization of β-catenin and RX-5902 binding to phospho-p68 RNA helicase by molecular dynamics simulation. Progress in Biophysics and Molecular Biology.
  11. Batool, A., Kamal, M. A., Rizvi, S. M. D., & Rashid, S. (2018). Topical discoveries on multi-target approach to manage Alzheimer’s Disease. Current Drug Metabolism.
  12. Younis, S., & Rashid, S. (2017). Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; A molecular dynamics study. PLOS ONE, 12(12), e0189154.
  13. Shafique, S., Ali, W., Kanwal, S., & Rashid, S. (2017). Structural basis for Cullins and RING component inhibition. International Journal of Biological Macromolecules.
  14. Channar, P. A., Saeed, A., Larik, F. A., Rashid, S., Iqbal, Q., Rozi, M., & Mahar, J. (2017). Design and synthesis of thiazolo-triazoles as α-glucosidase inhibitors. Biomedicine & Pharmacotherapy, 94, 499-513.
  15. Fakhar, M., & Rashid, S. (2017). Targeted inhibition of Klotho binding to fibroblast growth factor 23 prevents hypophosphatemia. Journal of Molecular Graphics and Modelling.
  16. Raza, S. I., Navid, A. K., Noor, Z., Shah, K., Dar, N. R., Ahmad, W., & Rashid, S. (2017). GLY67ARG substitution in RSPO4 disrupts the WNT signaling pathway. RSC Advances, 7(28), 17357-17366.
  17. Batool, A., Yasmeen, S., & Rashid, S. (2017). T8M mutation in connexin-26 leading to non-syndromic hearing loss. Journal of Molecular Liquids, 227, 168-177.
  18. Shafique, S., & Rashid, S. (2016). Antiviral drug Acyclovir exhibits antitumor activity via targeting βTrCP1. Journal of Molecular Graphics and Modelling.
  19. Shafique, S., Younis, S., Niaz, H., & Rashid, S. (2016). Structural characterization of βTrCP1 substrates via molecular dynamics study. Molecular BioSystems, 12(7), 2233-2246.
  20. Shafique, S., Bibi, N., & Rashid, S. (2016). Identification of bifunctional Plk1 inhibitors by integrative virtual screening. Journal of Theoretical Biology, 388, 72-84.
  21. Noor, Z., Afzal, N., & Rashid, S. (2015). Exploration of novel inhibitors for Histone Deacetylase Isoforms by QSAR modeling. PLOS ONE, 10(11).
  22. Rashid, S., Bibi, N., Parveen, Z., & Shafique, S. (2015). Inhibition of Janus kinases by Tyrphostin AG-490. Journal of Biomolecular Structure and Dynamics, 33(11), 2368-2379.
  23. Al-Masoudi, N. A., et al. (2014). New CYP17 hydroxylase inhibitors. Archiv der Pharmazie, 347(12), 896-907.
  24. Parveen, Z., et al. (2014). Disruption of murine Tcte3-3 induces tissue specific apoptosis. Computational Biology and Chemistry, 53, 214-225.
  25. Sohail, I., & Rashid, S. (2014). Molecular dynamics regulation of Butyrylcholinesterase activity. CNS & Neurological Disorders-Drug Targets.
  26. Nawaz, M. S., et al. (2014). Computational study of human tyrosine hydroxylase mutants. CNS & Neurological Disorders-Drug Targets.
  27. Hassan, M., Sehgal, S. A., & Rashid, S. (2014). Regulatory cascade of neuronal loss and glucose metabolism. CNS & Neurological Disorders-Drug Targets.
  28. Raza, S. I., et al. (2014). In silico analysis of missense mutations in LPAR6. PLOS ONE, 9(8), e104756.
  29. Sehgal, S. A., Hassan, M., & Rashid, S. (2014). Pharmacoinformatics drug targets against migraine. Drug Design Development and Therapy, 8, 571.
  30. Hassan, M., Sehgal, S. A., & Rashid, S. (2014). Regulatory cascade of neuronal loss and glucose metabolism. CNS & Neurological Disorders-Drug Targets.
  31. Sehgal, S. A., Tahir, R. A., Shafique, S., Hassan, M., & Rashid, S. (2014). Molecular modeling and docking analysis of CYP1A1. J Theor Comput Sci.
  32. Greig, N. H., Nawaz, M. S., Rashid, S., & Kamal, M. A. (2014). Exploring N1-p-Fluorobenzyl-Cymserine as inhibitor of 5-Lipoxygenase. CNS & Neurological Disorders-Drug Targets.
  33. Aziz, A., et al. (2014). Novel homozygous mutations in the WNT10B gene. Gene, 534(2), 265-271.
  34. Kausar, S., et al. (2013). Comparative molecular docking analysis of Dynein Light Chain DYNLL1. PLOS ONE.
  35. Bibi, N., Parveen, Z., & Rashid, S. (2013). Identification of potential Plk1 targets. PLOS ONE, 8(8), e70843.
  36. Rashid, S., Parveen, Z., Ferdous, S., & Bibi, N. (2013). Mutually exclusive binding of APPL PH domain and Reptin. Computational Biology and Chemistry.
  37. Ain, Q. U., et al. (2013). Prediction of structure of human Wnt-CRD complex. PLOS ONE, 8(1), e54630.
  38. Khebichat, N., et al. (2013). Conformational search on tripeptide structures. Drug Designing.
  39. Batool, S., et al. (2013). Identification of novel Aurora kinase inhibitors. Enzyme Engineering.
  40. Seemab, U., et al. (2012). TrFAST transcription factor binding site prediction tool. Genomics Proteomics & Bioinformatics.
  41. Nawaz, M. S., & Rashid, S. (2012). MotViz motif prediction tool. Genomics Proteomics & Bioinformatics.
  42. Qurrat-Ul-Ain, S. U., Nawaz, S., & Rashid, S. (2011). Integrative analyses of conserved WNT clusters. Bioinformation.
  43. Saqib, M. A. N., et al. (2011). Genetic analysis of Pakistani families with achromatopsia. Japanese Journal of Ophthalmology.
  44. Torun, A., Rashid, S., et al. (2011). Regulation of canonical Wnt pathway by endocytic proteins. FEBS Journal.
  45. Rashid, S., Grzmil, P., et al. (2010). Disruption of murine dynein light chain gene Tcte3-3 results in asthenozoospermia. Reproduction.
  46. Rashid, S., Pilecka, I., et al. (2009). Endosomal adaptor proteins APPL1 and APPL2 activate β-catenin transcription. Journal of Biological Chemistry.
  47. Rashid, S., Breckle, R., et al. (2006). Murine Dnali1 gene encodes flagellar protein interacting with dynein heavy chain. Molecular Reproduction and Development.
  48. Rashid, S. (2006). Bioinformatics resource development in Pakistan: A review. Proceedings Pakistan Academy of Sciences, 43(4), 295.

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